Iipolyurethanes zisetyenziswa ngokubanzi kwizicelo zebhayomedical ezifana nesikhumba sokwenziwa, ibhedi yesibhedlele, iityhubhu zedialysis, izinto zepacemaker, iicatheters, kunye neengubo zotyando.I-biocompatibility, iipropathi zoomatshini, kunye neendleko eziphantsi zizinto eziphambili kwimpumelelo ye-polyurethanes kwicandelo lezonyango.

Ukuphuhliswa kokufakelwa ngokuqhelekileyo kufuna umxholo ophezulu wamacandelo e-biobased, kuba umzimba uyawagatya ngaphantsi.Kwimeko ye-polyurethanes, i-biocomponent inokwahluka ukusuka kwi-30 ukuya kwi-70%, eyenza umda obanzi wokusetyenziswa kwiindawo ezinjalo (2).I-biobased polyurethanes iyasinyusa isabelo sazo semarike kwaye kulindeleke ukuba ifikelele malunga ne-42 yezigidi zeedola ngo-2022, eyipesenti encinci yemarike ye-polyurethane iyonke (ngaphantsi kwe-0.1%).Nangona kunjalo, yindawo ethembisayo, kwaye uphando olunzulu luyaqhuba malunga nokusetyenziswa kwezinto ezininzi ze-biobased kwi-polyurethanes.Uphuculo luyafuneka kwiipropati ze-biobased polyurethanes ukuhambelana neemfuno ezikhoyo, ukwenzela ukwandisa utyalo-mali.

I-Biobased crystalline polyurethane yenziwe ngendlela yokusabela kwe-PCL, i-HMDI, kunye namanzi adlale indima ye-chain extender (33).Iimvavanyo zokwehlisa umgangatho zenziwa ukufunda ukuzinza kwe-biopolyurethane kulwelo olulinganisiweyo lomzimba, olufana ne-phosphate-buffered saline solution.Iinguqu

kwi-thermal, mechanical, and physical properties zahlalutywa kwaye zithelekiswa nokulingana

i-polyurethane efunyenwe ngokusebenzisa i-ethylene glycol njengendawo yokwandisa ikhonkco endaweni yamanzi.Iziphumo zabonisa ukuba i-polyurethane efunyenwe kusetyenziswa amanzi njenge-chain extender ibonise iimpawu ezingcono ekuhambeni kwexesha xa kuthelekiswa nokulingana kwayo kwepetrochemical.Oku akunciphisi kakhulu kuphela

iindleko zenkqubo, kodwa ikwabonelela ngendlela elula yokufumana izinto zonyango ezongeziweyo ezifanelekileyo kwi-joint endoprostheses (33).Oku kwalandelwa yenye indlela esekwe kule ngcamango, eyenze i-biopolyurethane urea ngokusebenzisa i-polyol esekelwe kwi-oyile ye-rapeseed, i-PCL, i-HMDI, kunye namanzi njenge-chain extender (6).Ukwandisa indawo ephezulu, i-sodium chlorine yayisetyenziselwa ukuphucula i-porosity yeepolymers ezilungiselelwe.I-polymer eyenziwe yasetyenziswa njenge-scaffold ngenxa yesakhiwo sayo esinemingxuma ukuphembelela ukukhula kweeseli zethambo lethambo.Ngeziphumo ezifanayo xa kuthelekiswa

kumzekelo wangaphambili, i-polyurethane evezwe kulwelo lomzimba olufanisiweyo ibonise uzinzo oluphezulu, ibonelela ngokhetho olusebenzayo lwezicelo zescaffold.I-polyurethane ionomers yenye iklasi enomdla yeepolymers ezisetyenziselwa ukusetyenziswa kwe-biomedical, ngenxa ye-biocompatibility yazo kunye nokusebenzisana okufanelekileyo kunye nokusingqongileyo komzimba.I-polyurethane ionomers ingasetyenziswa njengamalungu etyhubhu kwi-pacemakers kunye ne-hemodialysis.34, 35).

Uphuhliso lwenkqubo yokuhanjiswa kweziyobisi esebenzayo ngummandla wophando obalulekileyo okwangoku ogxile ekufumaneni iindlela zokulwa nomhlaza.I-amphiphilic nanoparticle ye-polyurethane esekelwe kwi-L-lysine yalungiselelwa ukuhanjiswa kweziyobisi (36).Le nanocarrier

yalayishwa ngokufanelekileyo nge-doxorubicin, olunyango olusebenzayo lwechiza kwiiseli zomhlaza (Umfanekiso we-16).Amacandelo e-hydrophobic e-polyurethane asebenzisana neziyobisi, kunye namacandelo e-hydrophilic asebenzisana neeseli.Le nkqubo yenza i-core-shell structure ngokusebenzisa i-self-assembly

indlela kwaye ikwazile ukuhambisa amachiza ngokufanelekileyo ngeendlela ezimbini.Okokuqala, impendulo ye-thermal ye-nanoparticle yenza njenge-trigger ekukhululeni iyeza kwiqondo lokushisa lomhlaza weseli (~ 41-43 ° C), okuyimpendulo ye-extracellular.Okwesibini, amacandelo e-aliphatic e-polyurethane ahlupheke

i-enzymatic biodegradation ngesenzo se-lysosomes, evumela ukuba i-doxorubicin ikhutshwe ngaphakathi kwiseli yomhlaza;le yimpendulo ye-intracellular.Ngaphezulu kwe-90% yeeseli zomhlaza webele zabulawa, ngelixa i-cytotoxicity ephantsi igcinwe kwiiseli eziphilileyo.

Umfanekiso we-16. Isikimu esipheleleyo senkqubo yokuhanjiswa kweziyobisi esekelwe kwi-amphiphilic polyurethane nanoparticle

ukujolisa kwiiseli zomhlaza. Iveliswe kwakhona ngemvume evela kwireferensi(36).Copyright 2019 American Chemical

Uluntu.

Isibhengezo:Inqaku licatshulwe kuloIntshayelelo yePolyurethane ChemistryFelipe M. de Souza, 1 Pawan K. Kahol, 2 kunye noRam K.Gupta *,1.Kuphela ukunxibelelana kunye nokufunda, ungenzi ezinye iinjongo zorhwebo, ayimeli iimbono kunye nezimvo zenkampani, ukuba ufuna ukuphinda uprinte, nceda uqhagamshelane nombhali wokuqala, ukuba kukho ukuphulwa, nceda uqhagamshelane nathi ngokukhawuleza ukwenza ukucima ukusetyenzwa.